Synthesis and nematocidal activities of new analogs of pyrantel
| Autor: | R Caujolle, Philippe M. Loiseau, Christian Bories, M. Payard, S. Labidalle, N. Kraouti, Philippe Gayral |
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| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
biology Chemistry Organic Chemistry General Medicine Keto–enol tautomerism biology.organism_classification Tautomer Chemical synthesis chemistry.chemical_compound Intramolecular force Pyrantel Drug Discovery Butyllithium medicine Organic chemistry Nippostrongylus brasiliensis Tetrahydrofuran medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 30:509-513 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/0223-5234(96)88262-6 |
| Popis: | Summary A set of new analogs of pyrantel was synthesized in good yields by lithiation of 1,2-dimethyltetrahydropyrimidine with n -butyllithium in tetrahydrofuran and condensation with aromatic esters. Spectrometric studies showed the large influence of intramolecular bonding in the tautomeric equilibria between the possible structures. Anthelmintic screening showed in vitro efficiency against Molinema dessetae , but a weak activity against Rhabditis pseudoelongata and Nippostrongylus brasiliensis . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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