Triazolopyrimidinones as γ-secretase modulators: structure–activity relationship, modulator profile, and in vivo profiling

Autor: Fredrik Olsson, Krisztián Bogár, Per I. Arvidsson, Daniel Bergström, Paulina Appelkvist, Jonas Malmborg, Rebecka Klintenberg, Fredrik Lake, Kia Strömberg, Christian Linde, Istvan Macsari, Ellen Santangelo, Ann-Cathrine Radesäter, Kim Paulsen, Ulrika Yngve, Yevgeni Besidski, M. Sundstrom
Rok vydání: 2013
Předmět:
Zdroj: MedChemComm. 4:422
ISSN: 2040-2511
2040-2503
DOI: 10.1039/c2md20312j
Popis: The structure–activity relationship for a series of potent γ-secretase modulators based on the 6,7-dihydro-4H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one scaffold is described. Furthermore, we report details regarding the modulator profile on Aβ processing, as well as in vivo efficacy, for the optimized compounds.
Databáze: OpenAIRE
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