Comparative sensitivities and specificities of the mass measurements of CK-MB2, CK-MB, and myoglobin for diagnosing acute myocardial infarction
| Autor: | M Usategui, J Chang, N Kessimian, J P Laurino, E W Bender, T Pelletier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
education.field_of_study
medicine.medical_specialty biology business.industry Biochemistry (medical) Clinical Biochemistry Population medicine.disease QT interval Confidence interval chemistry.chemical_compound Endocrinology Myoglobin chemistry Internal medicine medicine biology.protein Cardiology Creatine kinase Myocardial infarction Myocardial infarction diagnosis education business Quantitative analysis (chemistry) |
| Zdroj: | Clinical Chemistry. 42:1454-1459 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | We evaluated the clinical utility of the mass measurement of the tissue isoform of creatine kinase MB isoenzyme (CK-MB2) in the diagnosis of an acute myocardial infarction (AMI) by determining its sensitivity, specificity, and predictive value relative to those of CK-MB mass and myoglobin. Samples were obtained at 0, 4, 8, and 16 h postpresentation from 100 patients (41% with AMI). The order of sensitivity for the sample proportions taken at 0-2 h from the onset of symptoms was myoglobin > CK-MB2 > CK-MB. At all other time points, the sensitivity of CK-MB2 either equaled or surpassed that of both CK-MB and myoglobin, although the 95% confidence intervals for the population proportions each of these markers overlapped. Of the 41 AMI patients, 31 (76%) exhibited concurrent abnormal increases of CK-MB and %CK-MB2; the other 10 (24%; 8 non-Q wave, 2 Q wave) exhibited abnormal values for %CK-MB2 before their CK-MB exceeded the upper limit of normal. The specificity of myoglobin was statistically lower than that for either CK-MB2 or CK-MB at all time points. |
| Databáze: | OpenAIRE |
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