Polymer-immobilized fluorinase: Recyclable catalyst for fluorination reactions

Autor:	Federica Morgia, Muhammad Rashed Javed, Maxim Sergeev, Mami Doi, Pei Yuin Keng
Rok vydání:	2013
Předmět:	chemistry.chemical_classification biology GLYCOL DIMETHACRYLATE Process Chemistry and Technology Bioengineering Fluorinase Polymer Biochemistry Recyclable catalyst Catalysis Enzyme catalysis chemistry.chemical_compound chemistry Yield (chemistry) biology.protein Organic chemistry Fluoride
Zdroj:	Journal of Molecular Catalysis B: Enzymatic. 92:51-56
ISSN:	1381-1177
DOI:	10.1016/j.molcatb.2013.03.009
Popis:	Polymer-immobilized fluorinase for the synthesis of 5′-fluoro-5′-deoxyadenosine (FDA) from S-adenosyl- l -methionine (SAM) and fluoride ion in aqueous media is described. The optimal composition of the poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) and the heterogeneous catalytic reaction conditions were developed to yield FDA in 49% within 150 min. In PET radiochemistry, using [ 18 F]fluoride ion in [ 18 O]H 2 O obtained from the cyclotron, [ 18 F]FDA was synthesized with 68% fluorination efficiency. The immobilized fluorinase was recycled for up to four runs with 80% of catalytic activity in the final cycle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57f48832b4edb86750240035cb42cddf https://doi.org/10.1016/j.molcatb.2013.03.009 Zobrazit plný text záznamu Full Text from ScienceDirect