Antibacterial activity of South African medicinal plants against methicillin resistantStaphylococcus aureus
| Autor: | Ahmed Hussein, Namrita Lall, J.J.M. Meyer, Heino M. Heyman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
biology Dodonaea viscosa Pharmaceutical Science General Medicine Withania somnifera Melianthus comosus biology.organism_classification medicine.disease_cause Methicillin-resistant Staphylococcus aureus Melianthus major Microbiology Complementary and alternative medicine Zygophyllaceae Staphylococcus aureus Drug Discovery medicine Molecular Medicine Medicinal plants |
| Zdroj: | Pharmaceutical Biology. 47:67-71 |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | The rise of infection caused by ‘superbugs’ is alarming and one of the most problematic resistant bacteria is methicillin-resistant Staphylococcus aureus (MRSA). This bacterium can cause a range of ailments like pneumonia, mastitis, meningitis, urinary tract infection, and post operational infection. Ten medicinal plants were investigated for their efficacy against drug-sensitive and drug-resistant strains of S. aureus. Ethanol extracts of Melianthus comosus Vahl (Melianthaceae), Melianthus major L (Melianthaceae), Dodonaea viscosa Jacq. var. angustifolia (L.f.) Benth (Sapindaceae) and Withania somnifera L. Dunal (Zygophyllaceae) were found to have good inhibitory activity against both drug-sensitive and drug-resistant strains of S. aureus. Minimum inhibitory concentrations of these plants ranged from 0.391 to 1.56 mg/ml. Ethanol extracts of all these plants were further tested for cytotoxicity on Vero cells using the XTT method. M. major exhibited a 50% inhibitory concentration (IC50) of 52.76 μg/ml and ... |
| Databáze: | OpenAIRE |
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