ChemInform Abstract: Catalytic Asymmetric 1,6-Conjugate Addition of para-Quinone Methides: Formation of All-Carbon Quaternary Stereocenters

Autor:	Zhaobin Wang, Jianwei Sun, Yuk Fai Wong
Rok vydání:	2016
Předmět:	Chemistry Organocatalysis Intermolecular force Para-quinone chemistry.chemical_element General Medicine Brønsted–Lowry acid–base theory Combinatorial chemistry Carbon Catalysis Stereocenter Conjugate
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201611055
Popis:	Described herein is a general and mild catalytic asymmetric 1,6-conjugate addition of para-quinone methides (p-QMs), a class of challenging reactions with previous limited success. Benefiting from chiral Bronsted acid catalysis, which allows in situ formation of p-QMs, our reaction expands the scope to general p-QMs with various substitution patterns. It also enables efficient intermolecular formation of all-carbon quaternary stereocenters with high enantioselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57f1c2d7e6a3b0a915cb4ec6bf0fe3f6 https://doi.org/10.1002/chin.201611055 Zobrazit plný text záznamu Plný text