Diagnosis of Nosocomial Pneumonia in Cancer Patients Undergoing Mechanical Ventilation
| Autor: | Françoise Doyon, François Blot, B. Leclercq, Gérard Nitenberg, Sami Antoun, Michel Casetta, Cyrille Tancrede |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Mechanical ventilation medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Respiratory disease Ventilator-associated pneumonia Critical Care and Intensive Care Medicine medicine.disease Surgery Pneumonia Catheter Bronchoscopy Intensive care medicine Cardiology and Cardiovascular Medicine business Prospective cohort study |
| Zdroj: | Chest. 115:1641-1645 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.115.6.1641 |
| Popis: | Study objectives Quantitative culture of protected samples of lower respiratory tract secretions obtained by a fiberoptic protected specimen brush (PSB) is widely accepted for the diagnosis of ventilator-associated pneumonia (VAP), but this diagnostic procedure is time consuming, expensive, and may give rise to iatrogenic complications, especially in cancer patients who often present with thrombocytopenia. The plugged telescoping catheter (PTC) could be a satisfactory alternative to the PSB in this setting. The aim of the present study was to evaluate the interest of the PTC to diagnose VAP in ventilated cancer patients. Design A prospective observational study. Setting A 15-bed medical-surgical ICU in a comprehensive cancer center. Patients and interventions Over a 9-month period, 42 patients suspected of having bacterial VAP during mechanical ventilation underwent 69 bronchial samplings: a blinded PTC and a fiberoptic PSB were performed successively in each case. A positive culture for both sampling procedures was defined as the recovery of > or = 10(3) cfu/mL of at least one potential pathogen. The PSB result was taken as the reference standard. Measurements and results The overall agreement between the techniques was 87% (60/69). PTC had a sensitivity of 67%, a specificity of 93%, a positive predictive value of 71%, and a negative predictive value of 91%. Conclusions We conclude that the accuracy of the blinded PTC compares well with that of the PSB for the diagnosis of VAP in cancer patients. The sensitivity of the PTC observed herein, which is slightly lower than that described in previous studies, may be due to the blinded nature of the method: the indications for initial or secondary coupling with a directed sampling method in patients with suspicion of localized pneumonia remain to be determined. |
| Databáze: | OpenAIRE |
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