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Background and objectives: Premenstrual syndrome includes physical and mental symptoms occurring cyclically during the secretory phase. The present study aimed to specify the association between neuroticism and the severity of premenstrual syndrome symptoms. Method: This cross-sectional study was conducted on 223 students of Kerman University of Medical Sciences in 2019 November 17. Chi-square and Fisher’s exact tests were used to analyze the relationship between qualitative variables; stepwise logistic regression was employed to assess the factors affecting the syndrome symptoms, and Mann–Whitney U test was used to compare the scores of the Daily Record of Severity of Problems chart in two groups. Findings: 223 female students completed the first stage information. The mean score of the questionnaire was 151.72±100.11. Moreover, 77.6% of the students had the syndrome. The severity of symptoms was mild, moderate, severe, and highly severe in 53.6, 42, 3.6, and 0.7%, respectively. There was a significant relationship between premenstrual syndrome and neuroticism scores. Students with PMS had higher scores in all of the subscales (neuroticism including anxiety, stress, despair,..) (P |