Transient High Titers of HIV-1 in Plasma and Progression of Disease

Autor: B Sheff, C. Van Der Horst, Susan A. Fiscus, Luigi Troiani, James D. Folds, E Wallmark, A Heggem-Snow
Rok vydání: 1995
Předmět:
Zdroj: Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology. 9:51
ISSN: 1077-9450
DOI: 10.1097/00042560-199505010-00008
Popis: Periodic quantitative HIV-1 plasma cultures were performed on 28 seropositive individuals who had CD4 cells or = 1,000 tissue culture infective dose/ml of plasma) seen in 11 individuals. These peaks in plasma culture titers were significantly associated either with rapidly decreasing CD4 cell numbers or with CD4 cells already < 50/mm3. In addition, patients who experienced these episodes of high-titered plasma viremia were more apt to have clinical complaints of fever, rash, flu-like illness, and/or opportunistic infection and also the syncytium-inducing HIV-1 phenotype and progression of disease.
Databáze: OpenAIRE