The structure and pharmacological properties of the 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine inclusion complex with β-cyclodextrin
| Autor: | V. T. Panyushkin, R. A. Sharipov, V. K. Yu, V. A. Volynkin, K. S. Sharapov, K. D. Praliev, U. S. Kemel’bekov |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin 010405 organic chemistry Chemistry Stereochemistry General Chemistry Nuclear magnetic resonance spectroscopy 010402 general chemistry Condensed Matter Physics 01 natural sciences Acute toxicity 0104 chemical sciences chemistry.chemical_compound Infiltration anaesthesia 4-Phenylpiperidine Thermal analysis Food Science |
| Zdroj: | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 87:141-148 |
| ISSN: | 1573-1111 1388-3127 |
| Popis: | Inclusion complex of 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine with β-cyclodextrin was synthesized. Composition (1:2) and the structure of the complex were confirmed by NMR spectroscopy and thermal analysis. The results of pharmacological studies showed that the compound is of interest for in-depth testing, because of its deeper and more prolonged conduction anaesthesia, terminal (superficial) and infiltration anaesthesia along with less acute toxicity compared to the reference preparations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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