Preparation and Study on the Single-Crystal Structure of Flurbiprofen–Salicylamide Co-crystal
| Autor: | Yan-Qing Gong, Jia-Wei Hou, Gang Li, Li-Wen Ma, Hong-Juan Pan, Han-Bin Shan, Jia-Liang Zhong |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pharmaceutical Fronts. :e101-e108 |
| ISSN: | 2628-5096 2628-5088 |
| DOI: | 10.1055/s-0043-1769006 |
| Popis: | Co-crystals can improve the physicochemical properties of pharmaceutical active ingredients, and thus have great potential in improving drug performance. Some studies have obtained the powder spectrum of the co-crystal of flurbiprofen (FBP) and salicylamide (2-OHBZA) but have not obtained a single-crystal structure. In this study, co-crystals of FBP-2-OHBZA with a molar ratio of 1:1 were obtained by slow evaporation using ethyl acetate and tetrahydrofuran for verification. Density functional theory was used to optimize the structure of the hydrogen bond and π−π stacking formed by the co-crystal of FBP and 2-OHBZA. The assay results of the co-crystals of FBP-2-OHBZA are in good agreement with the calculated values reported. |
| Databáze: | OpenAIRE |
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