Modelling Erythrocytes as Point-Like O2 Sources in a Kroghian Cylinder Model

Autor: Louis Hoofd, Zdenek Turek, Cees Bos
Rok vydání: 1994
Předmět:
Zdroj: Advances in Experimental Medicine and Biology ISBN: 9781461360513
DOI: 10.1007/978-1-4615-2468-7_117
Popis: In modelling O2 transport to tissue, the capillary is often considered as a uniform oxygen source. Nevertheless, almost all the oxygen is supplied from the hemoglobin packed in single erythrocytes. Few literature models handle this particulate nature of blood O2 supply, and even fewer consider the consequences in a tissue pO2 model. Then, these particulate models are often too complicated or too laborious to be applied on large portions of tissue or on many tissue cases, as is needed for correct judgement of tissue oxygenation, e.g., as pO2 histograms. For a recent overview, see Popel (1989). Here, the simplest way of representing O2, sources, the point-like source, is worked out for handling erythrocytic O2 supply, and the consequences for tissue O2 considered referring to the simple basic configuration of the Krogh/Kety cylinder model.
Databáze: OpenAIRE