Motor and Behavioral Effects of Moringa oleifera Leaf Extract
| Autor: | Mohammed Ashique, Abderrahim Nemmar, Badreldin H. Ali, Aishwarya Ramkumar, Mohammed Al-Abri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Traditional medicine Moringa oleifera leaf extract Plant Science General Medicine Biology Moringa 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Complementary and alternative medicine Drug Discovery Motor activity 030217 neurology & neurosurgery |
| Zdroj: | Natural Product Communications. 13:1934578X1801300 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1801300126 |
| Popis: | Moringa oleifera is a medicinal plant widely used in many parts of the world for hypertension, pain and epilepsy. The aim of this study was to determine the effect of M. oleifera aqueous leaf extract on motor and behavioral activities of healthy mice. Male mice were randomly divided into a control group (given 0.9% NaCl orally) and three groups treated with the extract at doses of 100, 200, and 400 mg/kg/day for 14 consecutive days. Motor and behavioral activity were evaluated by quantifying motor activity, exploration (hole-board), neuro-muscular coordination (rota rod treadmill), pain (hot plate, cold-water tail flick, and acetic acid-induced abdominal constriction), and depression (forced swimming test, FST). Administration of M. oleifera extract had a significant and dose-dependent antinociceptive action in both thermal and chemical tests ( p < 0.05). The extract (400 mg/kg) caused a reduction in exploration activity and neuro-muscular coordination, and decreased the mobility time in the FST, suggesting an antidepressant-like action. Motor activity was not significantly affected by any of the doses used. The results suggest that the plant aqueous extract may have a dose-dependent central nervous system (CNS) depressant action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|