CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

Autor:	Glennis A. Logsdon, Gregory D. Van Duyne, Kushol Gupta, Samantha J. Falk, Ben E. Black, Evan M. Smoak, Sergei A. Vinogradov, Lucie Y. Guo, Lars E.T. Jansen, Nikolina Sekulic, Michael A. Lampson, Tomoyasu Mani
Rok vydání:	2015
Předmět:	Genetics Multidisciplinary biology Chromosome macromolecular substances Cell biology Histone H3 Histone Centromere Protein A Centromere Histone methylation biology.protein Nucleosome Histone code
Zdroj:	Science. 348:699-703
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1259308
Popis:	Building stable centromeres Each of our chromosomes has a single centromere, seen as a constriction during cell division, which is required for accurate chromosome segregation to daughter cells. Falk et al. show that the special histone protein known as CENP-A, which forms part of the nucleosomes at centromeres, makes the chromatin at these constrictions very stable and long-lived. This stability is conferred by a protein-binding partner, CENP-C, recruited to the centromere by the CENP-A histone. Binding of CENP-C to CENP-A–containing nucleosomes alters the behavior of the macromolecular centromere complex to help it maintain its identity Science , this issue p. 699
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57a6ac75efe086c945020aebf510db8a https://doi.org/10.1126/science.1259308 Zobrazit plný text záznamu Plný text ve formátu PDF