Fluorophore-tagged superparamagnetic iron oxide nanoparticles as bimodal contrast agents for MR/optical imaging
| Autor: | Sophie Laurent, Parvin Eghbali, Yones Mosaei Oskoei, Hassan Fattahi, Robert N. Muller |
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| Rok vydání: | 2015 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Fluorophore Materials science Nanoparticle 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Rhodamine chemistry.chemical_compound Nuclear magnetic resonance chemistry Rhodamine B 0210 nano-technology Iron oxide nanoparticles Superparamagnetism Magnetite Nuclear chemistry |
| Zdroj: | Journal of the Iranian Chemical Society. 13:87-93 |
| ISSN: | 1735-2428 1735-207X |
| Popis: | A stable bimodal contrast agent for both MRI and fluorescence imaging was prepared based on fluorescent superparamagnetic iron oxide nanoparticles. In order to increase the stability of the product in a physiological medium, the designed route for preparation of this bimodal contrast agent is based on covalent linkages. Superparamagnetic magnetite nanoparticles were prepared by a coprecipitation method in polyol media, and then the surface of nanoparticles was modified with 3-aminopropyltriethoxysilane (APTES) to introduce reactive amine groups on the surface of nanoparticles. The hybrid nanoparticles were obtained by conjugating rhodamine B to APTES-modified superparamagnetic Fe3O4 nanoparticles through amide linkage. Longitudinal (r 1) and transverse (r 2) proton relaxivities and their ratio (r 2/r 1) obtained for bimodal contrast agent in different magnetic fields show their higher efficiency as T 2 contrast agent for MRI in comparison with commercially available magnetite-based contrast agents. Moreover, these nanoparticles can be followed up by fluorescence imaging. This study shows that rhodamine B-tagged iron oxide nanoparticles are well suited as a contrast agent for dual modality magnetic resonance and fluorescence imaging. |
| Databáze: | OpenAIRE |
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