PROMIS measures can be used to assess symptoms and function in long-term hematopoietic cell transplantation survivors
Autor: | Diane L. Fairclough, Karen L. Syrjala, Heather S.L. Jim, K. Scott Baker, Bronwen E. Shaw, Sarah A. Buckley, Lynn Onstad, Mary E.D. Flowers, Stephanie J. Lee, Eric J. Chow, Mary M. Horowitz |
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Rok vydání: | 2017 |
Předmět: |
Cancer Research
medicine.medical_specialty education.field_of_study Mental symptoms Hematopoietic cell business.industry Population Cancer Physical function medicine.disease Transplantation 03 medical and health sciences 0302 clinical medicine Oncology Quality of life Convergent validity 030220 oncology & carcinogenesis Internal medicine medicine Physical therapy education business 030215 immunology |
Zdroj: | Cancer. 124:841-849 |
ISSN: | 0008-543X |
Popis: | Background Patient-reported outcomes for hematopoietic cell transplantation (HCT) survivors are well characterized with established measures; however, there is little experience with the new, freely available Patient-Reported Outcomes Measurement Information System (PROMIS) measures in this population. The aim of this study was to compare the performance of the PROMIS measures in the HCT setting with the performance of the commonly used 36-Item Short Form Health Survey (SF-36). Methods Adult HCT survivors from the Fred Hutchinson Cancer Research Center (n = 4446) were mailed a survey that included the following as part of an annual follow-up survey: the Patient-Reported Outcomes Measurement Information System-Global Health (PROMIS-GH; 10 questions), the 29-Item Patient-Reported Outcomes Measurement Information System Profile (PROMIS-29), and the SF-36. Results Both the SF-36 and PROMIS measures were available for 1634 HCT recipients (503 autologous recipients and 1131 allogeneic recipients). The overall response rate was 46%. The median time after transplantation for allogeneic and autologous recipients was 12.0 years (range, 0.4-44.1 years) and 6.1 years (range, 0.4-30.1 years), respectively. With the SF-36 or PROMIS-GH, overall physical functioning was somewhat lower in comparison with the general population, but mental functioning was similar. Component and domain scores with similar contents were strongly correlated by Pearson correlation coefficients: the Global Health-Physical and SF-36 Physical Component Summary scores for autologous (r = 0.82) and allogeneic recipients (r = 0.83) and the PROMIS-29 and SF-36 physical function, pain, and vitality/fatigue scores for allogeneic (0.87, -0.82, and -0.82, respectively) and autologous recipients (0.84, -0.82, and -0.81, respectively). The correlation between the Global Health-Mental and SF-36 Mental Component Summary scores was lower (0.70 for autologous recipients and 0.72 for allogeneic recipients). Conclusions Physical and mental symptoms and function in autologous and allogeneic HCT survivors can be adequately assessed with PROMIS-29 and PROMIS-GH. Cancer 2018;124:841-9. © 2017 American Cancer Society. |
Databáze: | OpenAIRE |
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