Mucosal Uptake and Whole-Body Retention of Dietary Manganese Are Not Altered in β2-Microglobulin Knockout Mice
| Autor: | John W. Finley, Z. K. Roughead |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Beta-2 microglobulin Chemistry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Mutant chemistry.chemical_element General Medicine Manganese medicine.disease Biochemistry Dietary Manganese Inorganic Chemistry Endocrinology Intestinal mucosa Internal medicine Knockout mouse medicine Homeostasis Hemochromatosis |
| Zdroj: | Biological Trace Element Research. 80:231-244 |
| ISSN: | 0163-4984 |
| DOI: | 10.1385/bter:80:3:231 |
| Popis: | To further examine the interrelationships between manganese and iron absorption, the mucosal uptake, initial rate of loss, wholebody retention, and tissue distribution of an orally administered 54Mn radiotracer were compared between normal and β2-microglobulin knockout [β2m(-/-)] mice. These mutant mice are commonly used as a model for the study of human hemochromatosis, a hereditary ironoverload disease. Initial uptake of 54Mn by the intestinal mucosa, the liver, and the brain was not different between the two strains. The mutant mice had much higher concentrations of nonheme and total iron in the liver, but hepatic manganese, copper, magnesium, and zinc concentrations were similar between the two strains. In summary, the mucosal uptake and whole-body retention of manganese and tissue manganese concentrations were not altered in β2m(-/-) mice; this suggests that normal homeostasis of manganese is not affected by the altered HFE protein-β2m complex in these mice. |
| Databáze: | OpenAIRE |
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