Prevention of chronic erosive streptococcal cell wall-induced arthritis in rats by treatment with a monoclonal antibody against the T cell antigen receptor alpha beta

Autor:	S Yoshino, L G Cleland, G Mayrhofer, R R Brown, J H Schwab
Rok vydání:	1991
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 146:4187-4189
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.146.12.4187
Popis:	Rats treated with an mAb (R73) against the TCR-alpha beta failed to develop chronic persistent arthritis after injection of streptococcal cell walls. Histologically, R73 mAb-treated rats had mild hyperplasia of synovial lining cells and minimal destruction of cartilage. In contrast, control-treated animals developed marked pannus formation, with pronounced infiltration of mononuclear cells and severe destruction of cartilage and subchondral bone. The preventive effect of R73 mAb on streptococcal cell wall-induced arthritis was associated with the marked depletion of alpha beta + T cells by R73 mAb. These results indicate that T cells play a crucial role in chronic erosive streptococcal cell wall-induced arthritis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5796e68bf4d88f851302d78d72e25f2f https://doi.org/10.4049/jimmunol.146.12.4187 Zobrazit plný text záznamu