Radioactive Distribution of Tritium Labeled Acetophenone Derivative of 16 , 17 -Dihydroxyprogesterone

Autor:	Joseph P. Januszka, Leonard J. Lerner, Frank M. Singer, Aleck Borman, Euripides Yiacas, Arnold Taft
Rok vydání:	1965
Předmět:	Gastrointestinal tract chemistry.chemical_compound Chromatography Chemistry Distribution (pharmacology) Tritium Intramuscular injection General Biochemistry Genetics and Molecular Biology Derivative (chemistry) Acetophenone
Zdroj:	Experimental Biology and Medicine. 118:1051-1054
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-118-30043
Popis:	SummaryThe acetophenone derivative of 16α, 17α-dihydroxyprogesterone (D) was tritiated in the 6,7 position and was administered to rats by various routes. The major portion of the radioactivity was concentrated in the gastrointestinal tract 24 hours after the steroid was given orally, intravenously or intramuscularly. Radioactivity was found in the feces even at 28 days after a single intramuscular injection of 1 mg of D in oil. A high quantity of tritiated material was found in fatty tissue, suggesting that fat may serve as depot for the slow release of D. Radioactivity appeared in the blood one minute after the intramuscular injection of D in oil. The maximum concentration appeared within 15 minutes and was circulating 28 days after the material was given. Approximately 82% of the total radioactivity given was recovered on day 28.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57871345fc00dfd637bb2ee7062d9bc7 https://doi.org/10.3181/00379727-118-30043 Zobrazit plný text záznamu