Improved Process for a Copper-Catalyzed C–N Coupling in the Synthesis of Verubecestat

Autor:	John Limanto, Eric M. Phillips, Azzeddine Lekhal, Daniel Zewge, Mikhail Reibarkh, Minh Kieu
Rok vydání:	2019
Předmět:	chemistry.chemical_classification biology Organic Chemistry Nuclear magnetic resonance spectroscopy Combinatorial chemistry Enzyme chemistry Scientific method mental disorders Amyloid precursor protein biology.protein Copper catalyzed Verubecestat Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 23:1674-1678
ISSN:	1520-586X 1083-6160
Popis:	Verubecestat is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor which was previously evaluated for the treatment of Alzheimer’s disease. The synthesis of verubecestat relies ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5785f56ac4eff30128ef7df5636bad66 https://doi.org/10.1021/acs.oprd.9b00192 Zobrazit plný text záznamu