Microcapsule from PCL/PEG as Controlled Nifedipine Drug Delivery Carrier

Autor:	W. A. Rahma, E. Budianto
Rok vydání:	2021
Předmět:	History Nifedipine Chemistry Drug delivery PEG ratio medicine Pharmacology Computer Science Applications Education medicine.drug
Zdroj:	Journal of Physics: Conference Series. 1751:012081
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/1751/1/012081
Popis:	Problems related to controlled drug release are important to immediately find a solution because of the dangers of drug side effects if consumed repeatedly every day. The drug used is Nifedipine which is a hydrophobic drug. This research used a synthetic combination of poly(caprolactone) and poly(ethylene glycol) with surfactants in the form of tween 80 and span 80 while the method used was microencapsulation. Microencapsulation is a process in which active substances are coated by extremely small capsules. Once the drug was in the intestine, it was released in a controlled manner so as to minimize side effects and maximize drug release. The results showed that the composition of the best poly(caprolactone) (PCL): (PEG) poly(ethylene glycol) combination was 80:20 with a molecular weight of PEG 400 g/mol. The result of the encapsulation efficiency percentage obtained 97.84% ± 0.01 and the result of dissolution test was 44.77%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::57798250d5c2173a04f122718421e3ba https://doi.org/10.1088/1742-6596/1751/1/012081 Zobrazit plný text záznamu