FAST-TWITCH MUSCLE FIBERS HYPERTROPHY IS HAMPERED BY ANTIOXIDANT SUPPLEMENTATION DURING ATROPHY REHABILITATION IN RATS

Autor: Maurilio T. Dutra, Beshoy Girgis, Antonio Bovolini, José Alberto R. Duarte
Rok vydání: 2022
Předmět:
Zdroj: Journal of Musculoskeletal Research. 25
ISSN: 1793-6497
0218-9577
DOI: 10.1142/s0218957722500117
Popis: The role of antioxidant supplementation on muscle recovery after disuse is unknown. The aim was to investigate the effect of Vitamin C and E supplementation on muscle recovery after hindlimb suspension. Twenty-two Wistar rats were allocated into 4 groups: exercise with supplementation (VIT, [Formula: see text]); exercise with placebo (PLA, [Formula: see text]); hindlimb suspension (SUSP, [Formula: see text]), and control (CON, [Formula: see text]). All groups, except for CON, were submitted to a hindlimb suspension protocol for 10 days. Then, VIT and PLA underwent 10 days of a rehabilitation protocol consisting of exercise on a treadmill. VIT received vitamin C (250 mg/kg/day) and E (360 mg/kg) during rehabilitation. Samples of soleus and tibialis anterior were prepared for cross-sectional area (CSA) and biochemical analysis. Both VIT (1265.6[Formula: see text]m[Formula: see text]2, 95% CI: 1234.6–1290.3) and PLA (1280.9[Formula: see text]m[Formula: see text]2, 95% CI: 1296.4–1354.9) presented higher CSA of the soleus in relation to CON (816.66[Formula: see text]m[Formula: see text]2, 95% CI: 866.3–904.0, [Formula: see text] [Formula: see text] 0.05) with no difference between them. Both VIT (1276.9[Formula: see text]m[Formula: see text]2, 95% CI: 1378.7–1484.6) and PLA (1573.3[Formula: see text]m[Formula: see text]2, 95% CI: 1553.9–1651.5) presented higher tibialis anterior CSA in relation to CON (1041.56[Formula: see text]m[Formula: see text]2, 95% CI: 1119.1–1185.2, [Formula: see text] [Formula: see text] 0.05). In this muscle, CSA of PLA was higher than VIT ([Formula: see text] [Formula: see text] 0.05). Vitamin’s supplementation attenuated tibialis anterior hypertrophy following the rehabilitation protocol.
Databáze: OpenAIRE
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