Mapping the melatonin receptor. 2. synthesis and biological activity of indole derived melatonin analogues with restricted conformations of the C-3 amidoethane side chain

Autor: Sally J. Rowe, Peter J. Garratt, David Sugden, Stefan Vonhoff
Rok vydání: 1994
Předmět:
Zdroj: Bioorganic & Medicinal Chemistry Letters. 4:1559-1564
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(01)80566-7
Popis: A number of indole derived melatonin analogues have been prepared with the C-3 amidoethane side chain partially constrained by incorporation in a ring. The biological activity has been correlated with the conformation of the “side chain”, the nature of the N-acylating group, and the spatial distance between the methoxyl and amide functions.
Databáze: OpenAIRE