Influence of tobacco smoking on lipid peroxidation in exhaled breath condensate in asthma patients with exercise-induced bronchoconstriction (EIB)
| Autor: | Eugeniy A. Borodin, Leonid Nakhamchen, Anna Prikhodko, Juliy M. Perelman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Airway patency business.industry Airway hyperresponsiveness Optical density medicine.disease Gastroenterology Lipid peroxidation chemistry.chemical_compound chemistry Internal medicine Medicine Exhaled breath condensate Bronchoconstriction medicine.symptom Treadmill business Asthma |
| Zdroj: | Monitoring airway disease. |
| DOI: | 10.1183/13993003.congress-2020.135 |
| Popis: | Background: Airway hyperresponsiveness is related to the intensification of the lipid peroxidation (LP) in asthma. We aimed to study the effect of smoking on the LP status of asthma patients with EIB. Methods: 62 subjects (36.2±1.3 years) with EIB (drop of FEV1 -21.9±2.0%) were divided into 2 groups: the 1st included 30 non-smokers, the 2nd - 32 smokers (8.2±1.5 pack/year). The contents of conjugated dienes and non-oxidized lipids in the exhaled breath condensate were analyzed before and after 6-minute submaximal exercise on treadmill, using ultraviolet spectra of lipid extracts absorption and evaluated in terms of optical density at 233 nm (E233) and 206 nm (E206), respectively. Results: In group 2, FEV1 was lower (84.6±2.7 vs. 92.0±2.5%; p 0.05) in the2nd group led to a change in E233/E206 after exercise: 0.39±0.09 (p>0.05) vs. 0.38±0.05 (p Conclusion: Smoking in asthmatics with EIB leads to changes in the LP, which is accompanied by a deterioration of airway patency and a decrease of the response to dosed exercise. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|