A convenient synthesis of new pyrido[3,2-e][1,4]diazepine-2,5-diones and pyrido[2,3-e][1,4]diazepine-2,5-diones

Autor:	Mina Aadil, Hélène Laborie, Marie-Claude Viaud-Massuard, Said Lazar, Mohamed Akssira, Ahmed El Hakmaoui, Abderrahman El Bouakher
Rok vydání:	2011
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Ester derivatives Diazepine chemistry Organic Chemistry Drug Discovery Peptide Biochemistry Medicinal chemistry Tetrahydrofuran Sodium hydride
Zdroj:	Tetrahedron Letters. 52:5077-5080
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.07.098
Popis:	A convenient synthesis of a series of pyrido[3,2-e][1,4]-diazepine-2,5-diones 8 and pyrido[2,3-e][1,4]diazepine-2,5-diones 9, is reported using the condensation of α-amino acid methyl ester derivatives with 1H-pyrido[3,2-d][1,3]oxazine-2,4-dione and 1H-pyrido[2,3-d][1,3]oxazine-2,4-dione. Compounds 8 and 9 were also synthesized by peptide coupling of α-amino acid methyl ester derivatives with β-amino acids (2 or 3) followed by the cyclisation in tetrahydrofuran with sodium hydride (NaH).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::577116c0d4cc708dea6883b44ad4562c https://doi.org/10.1016/j.tetlet.2011.07.098 Zobrazit plný text záznamu Full Text from ScienceDirect