Multicentric reticulohistiocytosis: Case report with immunohistochemical analysis and literature review
| Autor: | Schumacher Hr, John H. Klippel, John C. Davis, Jennifer D. Gorman, C Danning |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cellular immunity
Pathology medicine.medical_specialty business.industry medicine.medical_treatment Immunology Multicentric reticulohistiocytosis Disease medicine.disease Pathogenesis Cytokine Rheumatology medicine Immunology and Allergy Immunohistochemistry Macrophage Pharmacology (medical) Histopathology business |
| Zdroj: | Arthritis & Rheumatism. 43:930 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/1529-0131(200004)43:4<930::aid-anr27>3.0.co;2-a |
| Popis: | This report describes the case of a patient with multicentric reticulohistiocytosis. Immunohistochemical analysis revealed prominent markers of monocyte/macrophage origin, as well as the presence of tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-12; the occurrence of the latter in this disease has not previously been reported. Clinical, laboratory, radiographic, and histologic findings in multicentric reticulohistiocytosis are reviewed. In addition, all published cases of multicentric reticulohistiocytosis which included reports of cytokine and immunohistochemical analysis are reviewed, and evidence for a monocyte/macrophage origin and role in disease pathogenesis is provided. |
| Databáze: | OpenAIRE |
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