A human-specific modifier of cortical circuit connectivity and function improves behavioral performance
| Autor: | Franck Polleux, Randy M. Bruno, Hanzhi T. Zhao, Ewoud R.E. Schmidt, Elizabeth M. C. Hillman, Jung M. Park, Jacob B. Dahan, Chris C. Rodgers |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Sensory processing Computer science medicine.medical_treatment Cognition Human brain Expression (mathematics) 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Sensory coding medicine 10. No inequality Human specific Neuroscience 030217 neurology & neurosurgery Function (biology) 030304 developmental biology SENSORY DISCRIMINATION |
| Popis: | SUMMARYThe remarkable cognitive abilities characterizing humans are thought to emerge from our unique features of cortical circuit architecture, including increased feedforward and feedback connectivity. However, our understanding of the evolutionary origin and nature of these changes in circuit connectivity, and how they impact cortical circuit function and behavior is currently lacking. Here, we demonstrate that expression of the human-specific gene duplication SRGAP2C leads to a specific increase in feedforward and feedback cortico-cortical connectivity. Moreover, humanized SRGAP2C mice display improved cortical sensory coding, and an enhanced ability to learn a cortex-dependent sensory discrimination task. Our results identify a novel substrate for human brain evolution whereby the emergence of SRGAP2C led to increased feedforward and feedback cortico-cortical connectivity, improved cortical sensory processing and enhanced behavioral performance. |
| Databáze: | OpenAIRE |
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