Acyl Radicals from Nitriles Promoted by Cp2TiCl in β-Lactam Chemistry

Autor:	Manuel Grande, Laura M. Monleón, Josefa Anaya
Rok vydání:	2010
Předmět:	Reaction conditions chemistry.chemical_classification chemistry.chemical_compound Nitrile chemistry Radical Organic Chemistry Lactam Organic chemistry Reactivity (chemistry) Aldehyde
Zdroj:	Synlett. 2010:1227-1230
ISSN:	1437-2096 0936-5214
Popis:	In order to synthesize new tricyclic β-lactams we have studied the reactivity of 4-alkenylepoxy-N-(1-cyano-1-dimethylethyl)-2-azetidinones with Cp 2 TiCl. The desired trilactams were not formed at all but an unsaturated nitrile and an aldehyde were obtained instead. Under similar reaction conditions, the treatment of styrylnitrile with Cp 2 TiCl afforded the styrylaldehyde. The formation of aldehydes in these reactions suggest the generation of acyl radicals from nitriles mediated by Cp 2 TiCl.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5752e2d1d12b79e97cf7fa446c621a76 https://doi.org/10.1055/s-0029-1219830 Zobrazit plný text záznamu