Heterosynaptic long-term potentiation of non-nociceptive synapses requires endocannabinoids, NMDARs, CamKII, and PKCζ

Autor:	Avery D. Franzen, Riley T. Paulsen, Emily J. Kabeiseman, Brian D. Burrell
Rok vydání:	2023
Předmět:	Physiology General Neuroscience
Zdroj:	Journal of Neurophysiology. 129:807-818
ISSN:	1522-1598 0022-3077
DOI:	10.1152/jn.00494.2022
Popis:	Pain-related sensitization involves increases in signaling by non-nociceptive sensory neurons. This can allow non-nociceptive afferents to have access to nociceptive circuitry. In this study, we examine a form of synaptic potentiation in which nociceptor activity elicits increases in non-nociceptive synapses. This process involves endocannabinoids, “gating” the activation of NMDA receptors, which in turn activate CamKII and PKCζ. This study provides an important link in how nociceptive stimuli can enhance non-nociceptive signaling related to pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5747c2d58bf3ff31fd87aa53fbdc3ce1 https://doi.org/10.1152/jn.00494.2022 Zobrazit plný text záznamu