Antitumor efficacy of Auger electron emitter 111In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression

Autor:	Tatiana A. Slastnikova, Alexander S. Sobolev, Yu. V. Khramtsov, Tatiana S. Karyagina, Andrey A. Rosenkranz, Georgii P. Georgiev
Rok vydání:	2017
Předmět:	0301 basic medicine Chemistry Biophysics Auger electron emitter General Chemistry General Medicine Biochemistry Molecular biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Folate receptor 030220 oncology & carcinogenesis Cervical carcinoma Cancer research
Zdroj:	Doklady Biochemistry and Biophysics. 473:85-87
ISSN:	1608-3091 1607-6729
DOI:	10.1134/s1607672917020016
Popis:	A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter 111In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new 111In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::573ba84085499bff0934862a87aa93b3 https://doi.org/10.1134/s1607672917020016 Zobrazit plný text záznamu Plný text ve formátu PDF