Hemocompatibility of zwitterionic interfaces and membranes

Autor:	Mei-Chan Sin, Yung Chang, Sheng-Han Chen
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Materials science Polymers and Plastics Polymer science Nanotechnology Polymer Methacrylate Polymer engineering Membrane chemistry Polymerization Materials Chemistry Surface modification Polymeric membrane Functional polymers
Zdroj:	Polymer Journal. 46:436-443
ISSN:	1349-0540 0032-3896
DOI:	10.1038/pj.2014.46
Popis:	This focused review addresses the fundamental development of nonfouling zwitterionic poly(sulfobetaine methacrylate) (polySBMA) coatings on a wide range of interfaces and membranes in our laboratory for use in the development of hemocompatible medical devices. The molecular designs of zwitterionic interfaces (for example, surface packing density, grafting coverage, polymer chain conformation and chemistry) as well as the evolution of ‘intelligent’ interfaces are scrutinized and discussed. Correlations between polymeric membrane surface modification methods, such as thermal- and plasma-induced polymerizations, the conformation of grafted polySBMA chains and hemocompatibility features, are also delineated. Fundamental development of nonfouling zwitterionic poly(sulfobetaine methacrylate) (polySBMA) coatings on a wide range of interfaces and membranes for use in the development of hemocompatible medical devices was discussed. The molecular designs of zwitterionic interfaces as well as the evolution of ‘intelligent’ interfaces and correlations between zwitterionic polymeric membrane surface modifications are scrutinized and delineated.
Databáze:	OpenAIRE
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