HBV Infection Statuses Indicate Different Risks of Synchronous and Metastasis Liver Metastasis in Colorectal Cancer

Autor: Jiaming Zhou, Pinzhu Huang, Xiaoyan Guo, Shuyun Tan, Rongwan Lin, Huanmiao Zhan, Xiaofeng Wu, Shaoyong Peng, Tuoyang Li, Mingzhe Huang, Yuanlv Xiao, Jianping Wang, Meijin Huang
Rok vydání: 2021
Předmět:
DOI: 10.21203/rs.3.rs-285576/v1
Popis: Background: Previous studies on the effect of HBV infection on CRLM are contrary. This study identified more specific and different impacts of HBV on CRLM.Methods: A total of 3132 CRC patients were analyzed retrospectively and followed up for five years. All patients were divided into three groups: group A, HBsAg positive with HBV infection; group B, HBsAg negative with HBV infection; and group C, no HBV infection. The risk factors for SYN-CRLM, MET-CRLM, 5-year OS, and LDFS were analyzed.Results: A total of 829 patients had CRLM. SYN-CRLM was found in 425 patients. The incidence of SYN-CRLM was 16.95%, 11.60% and 13.50% (P Conclusion: HBsAg positivity infection increased the risk of SYN-CRLM with poor prognosis. HBsAg-negative infection reduced the risk of MET-CRLM with better LDFS after surgery.
Databáze: OpenAIRE