Subakute sklerosierende Panenzephalitis (SSPE)
| Autor: | T Hoppen, M Rister, G Jacobi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Autopsy Neurological disorder medicine.disease biology.organism_classification Measles Subacute sclerosing panencephalitis Astrogliosis Central nervous system disease Measles virus Cerebrospinal fluid Pediatrics Perinatology and Child Health Immunology medicine business |
| Zdroj: | Klinische Pädiatrie. 215:268-270 |
| ISSN: | 1439-3824 0300-8630 |
| DOI: | 10.1055/s-2003-42671 |
| Popis: | Subacute sclerosing panencephalitis is a rare progressive neurological disorder of childhood and early adolescence caused by persistent measles virus. The diagnosis is based upon characteristic clinical manifestations, periodic EEG discharges, raised antibody titre against measles/SSPE in the plasma and cerebrospinal fluid and increase of gamma-globulins in the cerebrospinal fluid. Histopathological examination shows neuronal loss, astrogliosis, demyelination, infiltration of inflammatory cells, and intranuclear inclusions in neurons, oligodendrocytes and astrocytes. In most cases nucleocapsids are detected by electron microscopy. Although treatment is still undetermined, combination of intrathecal high-dose interferon-alpha and intravenous ribavirin administered at an early stage of SSPE seems to be effective. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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