Incorporation of primary amines into a poly(1,5-dioxepan-2-one) via lipase-catalyzed ring-opening polymerization
| Autor: | Bruno Danieli, Cristina Navarra, Raniero Mendichi, Sergio Riva, Mattia Marzorati |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
biology Process Chemistry and Technology Triacylglycerol lipase Bioengineering Biochemistry Ring-opening polymerization Catalysis Enzyme catalysis chemistry.chemical_compound chemistry Polymerization Amide biology.protein Organic chemistry Amine gas treating Lipase Lactone |
| Zdroj: | Journal of Molecular Catalysis B: Enzymatic. :158-161 |
| ISSN: | 1381-1177 |
| DOI: | 10.1016/j.molcatb.2007.10.016 |
| Popis: | A simple chemo-enzymatic strategy for the synthesis of functionalized poly(1,5-dioxepane-2-one)esters has been developed. The protocol involves first the reaction of a primary amine with 1,5-dioxepane-2-one (2) to give an amide carrying a terminal primary hydroxyl group, followed by an enzymatic ring-opening polymerization catalyzed by Novozym 435. The proposed method is easy to handle and is suitable for the incorporation of different amines, as it has been shown with the model benzyl amine (3), the functionalized amines tyramine (4) and propargylamine (5), and the bioactive compound N-deacetylthiocolchicine (6). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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