Perioperative Landiolol Infusion Reduces the Incidence of Atrial Fibrillation after Pulmonary Lobectomy: Postoperative Randomized Controlled Study
| Autor: | Jitsuo Usuda, Atsuhiro Sakamoto, Kaori Yagi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Bradycardia
medicine.medical_specialty business.industry Atrial fibrillation Perioperative Landiolol 030204 cardiovascular system & hematology medicine.disease Placebo Surgery 03 medical and health sciences Bilobectomy 0302 clinical medicine 030228 respiratory system Anesthesia medicine medicine.symptom Lung cancer Complication business medicine.drug |
| Zdroj: | Open Journal of Anesthesiology. :119-123 |
| ISSN: | 2164-5558 2164-5531 |
| DOI: | 10.4236/ojanes.2016.68020 |
| Popis: | Background and Objective: Atrial fibrillation is a common complication after lung resection. We sought to determine the relationship between low-dose landiolol only intraoperatively administration and the incidence of atrial fibrillation development in patients who did not have atrial fibrillation before undergoing lung resection. Methods: Forty-five patients undergoing lung resection (lobectomy or bilobectomy), as indicated for lung cancer at Nippon Medical Hospital, between August 2012 and September 2013. Two patients were excluded from the final analysis. Patients were given either intravenous landiolol (n = 22) or placebo (n = 21) during lobectomy or bilobectomy only intraoperatively. This is prospective, randomized, placebo-controlled study. Main Outcome Measures: The primary end point was the incidence of sustained atrial fibrillation (≥30 min). Results: Postoperative atrial fibrillation occurred in 1 (4.5%) of the 22 patients in the landiolol group and 6 (28.6%) of the 21 patients in the placebo group. No serious adverse effects such as bradycardia and hypotention secondary to landiolol were observed. Conclusion: Low-dose landiolol infusion intraoperatively reduced the incidence of clinically significant atrial fibrillation in patients undergoing pulmonary lobectomy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|