Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction
| Autor: | Helena Coutinho Franco de Oliveira |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Programmed cell death Chemistry Inflammation Lipid signaling Endothelial stem cell Endocrinology Internal medicine medicine lipids (amino acids peptides and proteins) medicine.symptom Intracellular Homeostasis Lipoprotein Polyunsaturated fatty acid |
| DOI: | 10.1016/b978-0-12-812348-5.00021-0 |
| Popis: | This chapter highlights the role of plasma lipoproteins and their associated components on the endothelial cell function and dysfunction by summarizing recent findings from experimental and clinical studies. Depending on the type of the lipoprotein, particularly its lipid composition, it may contribute to preserve endothelial homeostasis or, on the contrary, it may trigger endothelial malfunctioning. We describe the effects of oxidized phospholipids, saturated and polyunsaturated fatty acids, sphingosylphosphorylcholine, sphingosine-1-phosphate, and lysosulfatides, as well as some of their intracellular signaling leading to altered endothelial responses, such as vascular reactivity, permeability, inflammation and cell death. The knowledge about the interaction of lipoprotein lipid mediators and endothelial cell may reveal key molecules or events relevant for potential therapeutic interventions in the case of cardiovascular disease risk. |
| Databáze: | OpenAIRE |
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