Adverse Antibiotic Effects Associated with Renal Insufficiency

Autor:	William J. Stone, Robert H. Alford, Farrin A. Manian
Rok vydání:	1990
Předmět:	Microbiology (medical) medicine.medical_specialty business.industry Encephalopathy Renal function Hypoglycemia urologic and male genital diseases medicine.disease Uremia Nephrotoxicity Infectious Diseases Ototoxicity Toxicity medicine business Adverse effect Intensive care medicine
Zdroj:	Clinical Infectious Diseases. 12:236-249
ISSN:	1537-6591 1058-4838
Popis:	We review the English-language literature on antibiotic-associated adverse reactions in patients with renal insufficiency in order to highlight this important but often overlooked clinical problem. Because many adverse reactions to antibiotics are not dependent on renal function, we have attempted to review only those reactions that are believed to be associated with renal insufficiency or that have been reported in patients with impaired renal function. Adverse effects of antibiotics in this setting can be divided into six major categories: neurologic toxicity, coagulopathy, nephrotoxicity, hypoglycemia, hematologic toxicity, and aminoglycoside inactivation by penicillins. Neurologic toxicity can be further divided into central nervous system toxicity consisting primarily of encephalopathy and seizures, ototoxicity, peripheral neuropathy, and neuromuscular blockade/respiratory depression. We explore the factors in uremia that may contribute to the susceptibility of patients with renal insufficiency to the adverse effects of antibiotics. Moreover, we make general recommendations regarding the use of the discussed antibiotics in patients with compromised renal function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::571a260263ec0533a66e806928e079b5 https://doi.org/10.1093/clinids/12.2.236 Zobrazit plný text záznamu