ChemInform Abstract: Bacithrocins A, B and C, Novel Thrombin Inhibitors

Autor:	Sayoko Sawairi, Yoshiko Itezono, Kazuteru Yokose, Takayuki Umino, Tomoko Satoh, Tsutomu Kamiyama, Yumiko Nakamura
Rok vydání:	2010
Předmět:	Amino acid analysis Thrombin Clotting time Biochemistry Chemistry medicine General Medicine Trypsin circulatory and respiratory physiology medicine.drug Discovery and development of direct thrombin inhibitors Bacillus laterosporus
Zdroj:	ChemInform. 26
ISSN:	0931-7597
DOI:	10.1002/chin.199514240
Popis:	Novel thrombin inhibitors, bacithrocins A, B and C, have been isolated from the culture broth of Bacillus laterosporus Laubach NR 2988. The structures of these inhibitors have been determined to be N-acyl-L-phenylalanyl-DL-arginal by the 2D-NMR experiments on their oxidation products and by amino acid analysis. Bacithrocin A inhibits thrombin, factor Xa and trypsin with IC50s of 48, 13 and 0.65μM, respectively, which are similar to those of bacithrocins B and C. Bacithrocins prolong the clotting time induced by thrombin and factor Xa.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5715386a7ab31bba3bc0fe77d41e7358 https://doi.org/10.1002/chin.199514240 Zobrazit plný text záznamu Plný text