Square-wave voltammetric determination of clindamycin using a glassy carbon electrode modified with graphene oxide and gold nanoparticles within a crosslinked chitosan film
| Autor: | Tiago Almeida Silva, Ademar Wong, Orlando Fatibello-Filho, Claudia A. Razzino |
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| Rok vydání: | 2016 |
| Předmět: |
Detection limit
Materials science Graphene Supporting electrolyte Inorganic chemistry Metals and Alloys 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention Electrochemical gas sensor law Colloidal gold Electrode Materials Chemistry Electrical and Electronic Engineering Cyclic voltammetry 0210 nano-technology Instrumentation Voltammetry |
| Zdroj: | Sensors and Actuators B: Chemical. 231:183-193 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2016.03.014 |
| Popis: | An electrochemical method for the determination of clindamycin using a glassy carbon electrode modified with graphene oxide and gold nanoparticles within a film of crosslinked chitosan with epichlorohydrin (AuNPs-GO-CTS-ECH/GCE) is proposed. The electrochemical behavior of clindamycin was studied using cyclic voltammetry, and square-wave voltammetry (SWV). Under the optimized working conditions using 0.1 mol L−1 phosphate buffer (pH 7.0) solution as the supporting electrolyte, at a potential of +0.8 V vs. Ag/AgCl (3.0 mol L−1 KCl), using the SWV technique with the proposed AuNPs-GO-CTS-ECH/GCE electrode, the analytical curve showed a wide linear concentration range from 9.5 × 10−7 to 1.4 × 10−4 mol L−1, with a limit of detection of 2.9 × 10−7 mol L−1. The voltammetric method was successfully applied in the quantification of clindamycin in pharmaceutical formulations, as well as synthetic urine and river water samples, with results similar to those obtained by a comparative method (HPLC). |
| Databáze: | OpenAIRE |
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