Cytokine release syndrome in a patient with colorectal cancer following vaccination with BNT162b2 (tozinameran)

Autor: Camille L. Gerard, Eleanor Carlyle, Karolina Rzeniewicz, Robert Wilkinson, William Gordon, Scott Thomas Colville Shepherd, Kate Young, Lewis Au, Kim Edmonds, Samra Turajlic, Annika Fendler, Barry Ward, Ruth Harvey, Charlotte Fribbens, George Kassiotis, James E. Larkin, Winston A. Haynes, Katalin A. Wilkinson, Ian Chau, John Shon, Ben Shum, Charles Swanton, Lyra Del Rosario, Lisa Pickering, Naureen Starling, Andrew James Scott Furness, David K. Lau, Fiona Byrne, Nalinie Joharatnam-Hogan, Sonia Gandhi, Maddalena Cerrone, Wenyi Xie
Rok vydání: 2021
Předmět:
Popis: We present a case of cytokine release syndrome (CRS) that occurred five days after vaccination with BTN162b2 (tozinameran), an mRNA COVID-19 vaccine, in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-y/IL-2R/IL-18/IL-16/IL-10), and steroid responsiveness.
Databáze: OpenAIRE