Emerging spread of β-thalassemia trait in Nigeria
| Autor: | Temitope T. Alabi, Oluwaseyi E. Bamisaye, Olufemi E. Akanni |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty education.field_of_study medicine.diagnostic_test business.industry RED-CELL INDICES Thalassemia Population Complete blood count Physiology Hematology Disease medicine.disease 03 medical and health sciences 0302 clinical medicine Chronic anaemia Oncology hemic and lymphatic diseases 030220 oncology & carcinogenesis Genotype Medicine business education Pathological 030215 immunology |
| Zdroj: | Acta Haematologica Polonica. 48:35-39 |
| ISSN: | 0001-5814 |
| DOI: | 10.1016/j.achaem.2016.11.003 |
| Popis: | Background Chronic anaemia mainly thalassemia and sickle cell anaemia are inherited disorders of haemoglobin. Presently about 7% of the world's populations are carriers of a potentially pathological haemoglobin gene. Sickle cell disease is a common haemoglobinopathy in Nigeria but recently cases of β-thalassemia traits are becoming prominent. This study aimed at screening for β-thalassemia in adults and children with chronic anaemia in Nigeria by assessing the patients’ level of haemoglobin F, haemoglobin A2 and red cell indices. Materials and methods Haemoglobin F and HbA2 were determined in the chronic anaemia patients by Alkaline Denaturation Method and Beta-Thal HbA2 Quick Column Procedure respectively. Haemoglobin genotype was determined by Haemoglobin Electrophoresis at alkaline medium while Complete Blood count was estimated using Sysmex KX-2IN Autoanalyser. Results The mean HbF, HbA2, HCT, MCV, MCH and MCHC of the children and adults are 2.56 ± 0.46 and 2.45 ± 0.87 (%); 2.05 ± 0.25 and 1.89 ± 0.60 (%); 0.21 ± 0.31 and 0.21 ± 0.36 (L/L); 81.58 ± 12.59 and 78.69 ± 14.11 (fL); 22.74 ± 5.39 and 23.07 ± 7.36 (pg); 27.52 ± 3.84 and 31.23 ± 14.32 (g/l) respectively. Four percent (2 subjects) of each adult and children population had increased HbF level (>1.5%) and HbA2 levels (>2.8%) and these subjects are composed of 2 children with haemoglobin genotype AA and two adult with haemoglobin genotypes SS. Conclusions The outcome of this study reiterates the emergence of β-thalassemia traits and iron deficiency anaemia in different parts of Nigeria irrespective of their haemoglobin genotype status. This requires adequate specialized intervention for their diagnosis and treatment. There is therefore the need for subsequent molecular analysis to determine the β-thalassemia genes present in the studied community. |
| Databáze: | OpenAIRE |
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