Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile
| Autor: | Jared J. Godfrey, Noah Budi, Warren E. Rose, Sanjay K. Shukla, Nasia Safdar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
0303 health sciences 030306 microbiology medicine.drug_class fungi Antibiotics Clostridium difficile toxin A Biology Microbiology Spore 03 medical and health sciences Metronidazole chemistry.chemical_compound 0302 clinical medicine Infectious Diseases chemistry Germination Omadacycline medicine Vancomycin Pharmacology (medical) 030212 general & internal medicine Pathogen medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 65 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Clostridioides difficile (C. difficile) infections (CDI) are commonly treated with antibiotics that do not impact the dormant spore form of the pathogen. CDI-directed antibiotics, such as vancomycin and metronidazole, can destroy the vegetative form of C. difficile and protective microbiota. After treatment, spores can germinate into vegetative cells causing clinical disease relapse and further spore shedding. This in vitro study compares the combination of germinants with vancomycin or omadacycline to antibiotics alone in eradicating C. difficile spores and vegetative cells. Among the four strains in this study, omadacycline minimum inhibitory concentrations (0.031-0.125 mg/L) were lower than vancomycin (1-4 mg/L). Omadacycline nor vancomycin in media alone reduced spore counts. In three of the four strains, including the epidemic ribotype 027, spore eradication with germinants was 94.8-97.4% with vancomycin and 99.4-99.8% with omadacycline (p |
| Databáze: | OpenAIRE |
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