Novel synthesis of tetrahydro-2(1 H )-quinolones using Diels–Alder reactions of 1-arylsulfonyl-2(1 H )-pyridones having an electron-withdrawing group

Autor:	Wakako Ikeura, Reiko Fujita, Y. Harigaya, Hiroshi Hongo, Kazuhiro Watanabe, Hisao Matsuzaki, Yohsuke Ohtake
Rok vydání:	2001
Předmět:	Group (periodic table) Chemistry Organic Chemistry Drug Discovery Polar effect Diels alder Biochemistry Medicinal chemistry Diels–Alder reaction
Zdroj:	Tetrahedron. 57:8841-8850
ISSN:	0040-4020
Popis:	A novel synthetic methodology of preparing tetrahydro-2(1H)-quinolones by Diels–Alder reactions between 2-methyl- and 2,3-dimethyl-1,3-butadienes and 1-arylsulfonyl-2(1H)-pyridones having an electron-withdrawing group at the 5-position is presented. Furthermore, the site-selectivity analyses based on MO calculations of the 5-substituted 2(1H)-pyridones acting as the dienophiles are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5700d7ef0e79e7944477e04f950c9a66 https://doi.org/10.1016/s0040-4020(01)00893-6 Zobrazit plný text záznamu Full Text from ScienceDirect