Determination of acetaminophen using functional paper-based electrochemical devices
| Autor: | Woo Sung Chung, Joo Heon Lee, Gi Hun Seong, Euna Ko, Chan Ho Park, Sung Hwan Lee, Van-Khue Tran |
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| Rok vydání: | 2016 |
| Předmět: |
Detection limit
Materials science 010401 analytical chemistry Metals and Alloys Analytical chemistry 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics Electrochemistry Ascorbic acid 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Electrochemical gas sensor chemistry.chemical_compound chemistry Colloidal gold Nafion Electrode Materials Chemistry Electrical and Electronic Engineering 0210 nano-technology Instrumentation Nitrocellulose |
| Zdroj: | Sensors and Actuators B: Chemical. 232:514-522 |
| ISSN: | 0925-4005 |
| Popis: | In the present study, we constructed a functional paper fluidic device and evaluated its electrochemical performance by analyzing acetaminophen in the presence of ascorbic acid. The device was composed of a single-walled carbon nanotube (SWCNT) electrode and nafion-modified nitrocellulose membrane. Negatively-charged nafion was employed to build up a more negative charge on the nitrocellulose membrane, and gold nanoparticles and polyglutamic acid (AuNP-PGA) were deposited on the SWCNT electrode to enhance the electrochemical performance of the device. The device had a vertical flow format in which the sample solution flowed vertically through the paper. Using the nafion-modified nitrocellulose membrane and AuNP-PGA/SWCNT film electrode as a component of the paper fluidic device, we obtained a distinguishable acetaminophen oxidation peak which was distinct from the ascorbic acid oxidation peak. The acetaminophen oxidation peak had a linear response with acetaminophen concentration, varying from 50 μM to 300 μM (r 2 = 0.992), which was broader than the standard drug dose range. The device exhibited a sensitivity of 13.3 mA/M and a detection limit of 15.0 μM. The device was stable with a relative standard deviation of 3.3% (up to 2 weeks), and the reproducibility was 1.2–5.2%. Furthermore, the fabricated device accurately measured the amount of acetaminophen in pharmaceutical samples. |
| Databáze: | OpenAIRE |
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