Primary prevention and smoking habit among BRCA1/2 mutation carriers

Autor: Aurea Molina Diaz, Rocio Lesta, Begona Grana-Suarez, Cristina Reboredo Rendo, Carmen Cereijo Garea, Carlota Czestokowa, Javier Prato, Luis Albaina Latorre, Alberto Bouzón, Silvia Antolín Novoa, Patricia Cordeiro, Vanessa Suárez, Berta Rodríguez Sánchez, Belen Lopez Cortabitarte, María Eva Pérez López, Montserrat Rodríguez Pedreira, Maria Quindós Varela, Igor Gómez-Randulfe, Joaquín Martínez, Lourdes Calvo Martínez
Rok vydání: 2019
Předmět:
Zdroj: Journal of Clinical Oncology. 37:e13061-e13061
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2019.37.15_suppl.e13061
Popis: e13061 Background: Smoking is the leading cause of avoidable death in the world. Although controversial for years, current prospective studies suggest that smoking increases the risk of cancer in women with a deleterious BRCA1/2 mutation. Actually, we have very limited information about tobacco habit among BRCA1/2 carriers. Methods: We report an observational retrospective study of a consecutive sample of 198 BRCA1/2 carriers studied between April 2014 and March 2018 at the Family Cancer Clinic of the University Hospital of Coruña (NW-Spain). The main objective of the study is to know the prevalence of smoking in BRCA1/2 women, and to determine if carriers undergoing risk-reducing surgeries (RRS) abandon their tobacco habit as part of the primary prevention strategy. Results: The sample includes 136 patients affected by cancer (84% breast, 19% ovary) and 62 healthy women. During their follow-up [Median = 22, (1-43) months], 85 carriers underwent RRS (29% mammary, 54% prophylactic salpingo-oophorectomy, 16% both). At first visit, 46 were active smokers, 47 ex-smokers, 77 non-smokers and 28 did not specify their habit. The percentage of smokers and never smokers is similar between sick and healthy BRCA1/2 carriers, presenting a greater proportion of former smokers among those affected of cancer (30% vs. 23%), and of active smokers among healthy women (35% vs. 23%) [p > 0.5)]. Moreover, 23% of BRCA1/2 carriers are active smokers despite a previous diagnosis of cancer. RRS are not associated to a greater tobacco cessation, persisting in the habit 18% of the women that underwent any preventive surgery (p > 0.5). Conclusions: Smoking habit is high (55%) among BRCA1/2 carriers followed at our family cancer clinic. At least 23% of our BRCA1/2 positive women are active smokers despite a previous diagnosis of cancer.The performance of aggressive RRS is not associated with greater abandonment of tobacco in carriers, persisting in the smoking habit 18% of operated women.It is essential to improve anti-tobacco strategies in family cancer consultations if we want to be efficient in the management of high-risk cancer individuals.
Databáze: OpenAIRE
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