Evaluation of 9 Rapid Agglutination Tests for the Diagnosis of Typhoid and Parathyphoid Fever in Côte D'ivoire

Autor: Roseline Affi-Aboli, Bamory Dembele, Franck Stéphane Amani, André Inwoley, Aimé Césaire Adiko, Matthieu Kabran, Jean-Claude Seka, Nadège-Audrey Abiyou
Rok vydání: 2016
Předmět:
Zdroj: Open Medicine Journal. 3:243-248
ISSN: 1874-2203
DOI: 10.2174/1874220301603010243
Popis: Introduction:In Africa, the Widal test is done in the majority of laboratories by rapid tests whose performances are poorly documented. We evaluate the performance of 9 commercial rapid tests used in Côte d'Ivoire for the serodiagnosis of typhoid and paratyphoid fever.Methods:we used a panel of 170 samples collected from subjects suspected of typhoid or paratyphoid fever in Abidjan to determine the sensitivity, the specificity and operational characteristics of 9 plate agglutination tests (BIOREX®, BIOTEC®, CHRONOLAB®, CROMATEST®, FORTRESS®, PLASMATEC®, CYPRESS®, SPINREACT®and TYDAL®) compared to the reference technique SALMONELLA SEROLOGY®of BIORAD (tube agglutination).Results:Among the 9 evaluated tests, only BIOTEC®presented good performances (96% sensitivity and 97% specificity). Others gave sensitivities below 80%. Their characteristics were improved with the semi-quantitative plate agglutination test. All tests had good operational characteristics.Conclusion:In our context, the majority of tests evaluated should not be used to carry out the Widal test.
Databáze: OpenAIRE