EVALUATION OF SOMATIC CELL VARIANTS DEFICIENT IN GLYCOSYLPHOSPHATIDYL-INOSITOL ANCHORING AS CANDIDATES FOR GENETIC CORRECTION

Autor:	Claude Bron, Nicole Déglon, Michel Bernard, Marga Rousseaux, C. Beghdadi-Rais, Nicolas Fasel
Rok vydání:	1992
Předmět:	Somatic cell Cell Anchoring Biology Cell biology chemistry.chemical_compound medicine.anatomical_structure Biosynthesis chemistry Cell culture medicine lipids (amino acids peptides and proteins) Lipid bilayer Gene Glycosylphosphatidyl inositol
Popis:	Many cell surface glycoproteins are anchored in the lipid bilayer by a glycosylphosphatidyl-inositol (GPI) structure. Recently, a number of cell lines which are deficient in the biosynthesis and/or addition of this anchor have been described. In this report, we summarize the current knowledge on these lines and discuss their potential use to isolate the genes involved in the GPI anchor biosynthetic pathway with a specific emphasis on L cell fibroblasts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56f7e817201c240b41837431064c98d6 https://doi.org/10.1016/b978-0-12-159390-2.50018-0 Zobrazit plný text záznamu