No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial
| Autor: | Mads Klein, Bülent Kücükakin, Jacob Rosenberg, Russel J. Reiter, I. Gögenur, Jens Lykkesfeldt |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Placebo-controlled study General Medicine Ascorbic acid Malondialdehyde Placebo medicine.disease_cause Gastroenterology Melatonin chemistry.chemical_compound Anesthesiology and Pain Medicine chemistry Anesthesia Internal medicine medicine Cholecystectomy Dehydroascorbic acid business Oxidative stress medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 54:1121-1127 |
| ISSN: | 0001-5172 |
| DOI: | 10.1111/j.1399-6576.2010.02294.x |
| Popis: | Background: Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods: Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results: Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P>0.05 for all variables). Conclusions: Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|