| Autor: |
Rolf Tünnemann, Günther Jung, Frauke Palmer, Hans-Georg Mack, Christiane Stingel, V. Hoffmann |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 60:1739-1750 |
| ISSN: |
1386-1425 |
| DOI: |
10.1016/j.saa.2003.09.015 |
| Popis: |
The interaction of cyclic peptides with surface-bound model peptides was investigated by ATR–FTIR spectroscopy, principal components analysis and force field calculations. Information about the interacting functional COOH, COO−, and NH3+ groups and the peptide backbone was gained through a set of cyclohexapeptides (seven of the type c(X1KX2KX3K) (K = l -lysine) and one of the type c(X1KX2KX3k) (k = d -lysine), which are interacting with l -arginine- or tripeptide-coated Si–ATR crystals. All measurements were performed in aqueous solutions. Spectra evaluation in the range 1800–1500 cm−1 was done by band and principal components analysis (PCA). Only adsorbed molecules were present in these spectra. The coatings were investigated by ATR–FTIR spectroscopy too in order to characterise their functional groups. Based on this knowledge, the spectra of the interacting partners could be evaluated in relation to cyclohexapeptides and coatings. As a result, it was possible to identify the distinct differences in the bonding behaviour of the various peptides. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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