The Effect of Pulsed Magnetic Fields on the Production of Reactive Oxygen Species by Neutrophils

Autor: A. P. Kadyrkov, Valentin V. Novikov, E. V. Yablokova, E. E. Fesenko
Rok vydání: 2021
Předmět:
Zdroj: Biophysics. 66:614-622
ISSN: 1555-6654
0006-3509
Popis: It has been shown that pulsed magnetic fields (the first mode: pulse duration of 2 ms, frequency repetitions of 6.25 Hz, the pulse was bell-shaped; and the second mode: pulse duration of 1 ms, repetition frequency of 100 Hz, the pulse was bell-shaped) affected the intensity of luminol-dependent chemiluminescence of neutrophils in a wide range of pulsed magnetic fields (0.0004–10 mT). For the detection of the effects of pulsed magnetic fields by this method, it was necessary to add forbol-12-meristat-13-acetate, an activator of the production of reactive oxygen species, to the suspension of neutrophils. However, this mechanism of action of pulsed magnetic fields on the production of reactive oxygen species in neutrophils was not the only one, since lucigenin-dependent chemiluminescence also reacted to their action in a system without activators.
Databáze: OpenAIRE
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